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Volume of Distribution given Elimination Half Life Formula

GoVolume of Distribution given Volume of Plasma Cleared Formula

GoVolume of Distribution given Area under Curve Formula

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The Volume of Distribution is the parameter relating drug concentration in plasma to drug amount in the body. Check FAQs

V d = \frac{CL \cdot t b/2}{\ln (2)}

V_d - Volume of Distribution?CL - Volume of Plasma Cleared?t_b/2 - Elimination Half Life?

Volume of Distribution given Elimination Half Life Example

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Here is how the Volume of Distribution given Elimination Half Life equation looks like with Values.

Here is how the Volume of Distribution given Elimination Half Life equation looks like with Units.

Here is how the Volume of Distribution given Elimination Half Life equation looks like.

8.3099 = \frac{0.48 \cdot 12}{\ln (2)}

8.3099L = \frac{0.48L/s \cdot 12s}{\ln (2)}

8.3099 = \frac{0.48 \cdot 12}{\ln (2)}

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Volume of Distribution » fx Volume of Distribution given Elimination Half Life

Volume of Distribution given Elimination Half Life Solution

Follow our step by step solution on how to calculate Volume of Distribution given Elimination Half Life?

FIRST Step Consider the formula

V d = \frac{CL \cdot t b/2}{\ln (2)}

Next Step Substitute values of Variables

∴

V d = \frac{0.48L/s \cdot 12s}{\ln (2)}

Next Step Convert Units

∴

V d = \frac{0.0005m³/s \cdot 12s}{\ln (2)}

Next Step Prepare to Evaluate

∴

V d = \frac{0.0005 \cdot 12}{\ln (2)}

Next Step Evaluate

∴

V d = 0.00830992343552043m³

Next Step Convert to Output's Unit

∴

V d = 8.30992343552043L

LAST Step Rounding Answer

∴

V d = 8.3099L

Volume of Distribution given Elimination Half Life Formula Elements

Variables

Functions

Volume of Distribution

The Volume of Distribution is the parameter relating drug concentration in plasma to drug amount in the body.

Symbol: V_d

Measurement: VolumeUnit: L

Note: Value can be positive or negative.

Formulas to find Volume of Distribution

Volume of Plasma Cleared

The Volume of Plasma Cleared is defined as the amount of plasma cleared of the drug per unit of time.

Symbol: CL

Measurement: Volumetric Flow RateUnit: L/s

Note: Value can be positive or negative.

Formulas to find Volume of Plasma Cleared

Elimination Half Life

Elimination Half Life is the time required for the concentration of the drug to reach half of its original value.

Symbol: t_b/2

Measurement: TimeUnit: s

Note: Value should be greater than 0.

Formulas to find Elimination Half Life

The natural logarithm, also known as the logarithm to the base e, is the inverse function of the natural exponential function.

Syntax: ln(Number)

Other Formulas to find Volume of Distribution

Go Volume of Distribution given Volume of Plasma Cleared

V d = \frac{CL}{t b/2}

Go Volume of Distribution given Area under Curve

V d = \frac{D}{k e \cdot AUC}

Go Volume of Distribution of Drug Displacing into Body Tissue Relative to Blood

V d = V P + (V T \cdot (\frac{fu}{fu t}))

Other formulas in Volume of Distribution category

Go Volume of Distribution in Clearance of Drug

V d = \frac{K}{CL}

How to Evaluate Volume of Distribution given Elimination Half Life?

Volume of Distribution given Elimination Half Life evaluator uses Volume of Distribution = (Volume of Plasma Cleared*Elimination Half Life)/ln(2) to evaluate the Volume of Distribution, The Volume of distribution given elimination half life formula is defined as the direct relation with the product of the volume of plasma cleared of the drug per unit time and time required for the concentration of the drug to reach half of its original value. Volume of Distribution is denoted by V_d symbol.

How to evaluate Volume of Distribution given Elimination Half Life using this online evaluator? To use this online evaluator for Volume of Distribution given Elimination Half Life, enter Volume of Plasma Cleared (CL) & Elimination Half Life (t_b/2) and hit the calculate button.

FAQs on Volume of Distribution given Elimination Half Life

What is the formula to find Volume of Distribution given Elimination Half Life?

The formula of Volume of Distribution given Elimination Half Life is expressed as Volume of Distribution = (Volume of Plasma Cleared*Elimination Half Life)/ln(2). Here is an example- 8309.923 = (0.00048*12)/ln(2).

How to calculate Volume of Distribution given Elimination Half Life?

With Volume of Plasma Cleared (CL) & Elimination Half Life (t_b/2) we can find Volume of Distribution given Elimination Half Life using the formula - Volume of Distribution = (Volume of Plasma Cleared*Elimination Half Life)/ln(2). This formula also uses Natural Logarithm (ln) function(s).

What are the other ways to Calculate Volume of Distribution?

Here are the different ways to Calculate Volume of Distribution-

Volume of Distribution=Volume of Plasma Cleared/Elimination Half Life
Volume of Distribution=Dose/(Elimination Rate Constant*Area Under Curve)
Volume of Distribution=Plasma Volume+(Apparent Tissue Volume*(Fraction Unbound in Plasma/Fraction Unbound in Tissue))

Can the Volume of Distribution given Elimination Half Life be negative?

Yes, the Volume of Distribution given Elimination Half Life, measured in Volume can be negative.

Which unit is used to measure Volume of Distribution given Elimination Half Life?

Volume of Distribution given Elimination Half Life is usually measured using the Liter[L] for Volume. Cubic Meter[L], Cubic Centimeter[L], Cubic Millimeter[L] are the few other units in which Volume of Distribution given Elimination Half Life can be measured.

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