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Total Clearance of Body Formula

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The Total Clearance is the total clearance of a drug from the body. It is a measure of how quickly the drug is eliminated from the body. Check FAQs

CL total = CL hepatic + CL renal + CL pulmonary + CL other

CL_total - Total Clearance?CL_hepatic - Hepatic Clearance?CL_renal - Renal Clearance for Total?CL_pulmonary - Pulmonary Clearance?CL_other - Other Clearance?

Total Clearance of Body Example

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Here is how the Total Clearance of Body equation looks like with Values.

Here is how the Total Clearance of Body equation looks like with Units.

Here is how the Total Clearance of Body equation looks like.

5.2 = 1.5 + 2 + 1.5 + 0.2

5.2L/h = 1.5L/h + 2L/h + 1.5L/h + 0.2L/h

5.2 = 1.5 + 2 + 1.5 + 0.2

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Total Clearance of Body Solution

Follow our step by step solution on how to calculate Total Clearance of Body?

FIRST Step Consider the formula

CL total = CL hepatic + CL renal + CL pulmonary + CL other

Next Step Substitute values of Variables

∴

CL total = 1.5L/h + 2L/h + 1.5L/h + 0.2L/h

Next Step Convert Units

∴

CL total = 4.2E-7m³/s + 5.6E-7m³/s + 4.2E-7m³/s + 5.6E-8m³/s

Next Step Prepare to Evaluate

∴

CL total = 4.2E-7 + 5.6E-7 + 4.2E-7 + 5.6E-8

Next Step Evaluate

∴

CL total = 1.44444444444445E-06m³/s

LAST Step Convert to Output's Unit

∴

CL total = 5.2L/h

Total Clearance of Body Formula Elements

Variables

Total Clearance

The Total Clearance is the total clearance of a drug from the body. It is a measure of how quickly the drug is eliminated from the body.

Symbol: CL_total

Measurement: Volumetric Flow RateUnit: L/h

Note: Value should be greater than 0.

Formulas to find Total Clearance

Hepatic Clearance

The Hepatic Clearance is the clearance of a drug by the liver. The liver is a major organ for drug metabolism, and it is responsible for breaking down and eliminating many drugs from the body.

Symbol: CL_hepatic

Measurement: Volumetric Flow RateUnit: L/h

Note: Value should be greater than 0.

Formulas to find Hepatic Clearance

Renal Clearance for Total

The Renal Clearance for Total is the clearance of a drug by the kidneys. The kidneys are responsible for filtering out drugs from the blood, and they are a major route of drug elimination.

Symbol: CL_renal

Measurement: Volumetric Flow RateUnit: L/h

Note: Value should be greater than 0.

Formulas to find Renal Clearance for Total

Pulmonary Clearance

The Pulmonary Clearance is the clearance of a drug by the lungs. The lungs are responsible for exchanging gases in the blood, and they can also eliminate some drugs from the body.

Symbol: CL_pulmonary

Measurement: Volumetric Flow RateUnit: L/h

Note: Value should be greater than 0.

Formulas to find Pulmonary Clearance

Other Clearance

The Other Clearance is the clearance of a drug by other organs or tissues. There are organs and tissues that can contribute to the clearance of drugs, such as the gut, the brain, and the skin.

Symbol: CL_other

Measurement: Volumetric Flow RateUnit: L/h

Note: Value should be greater than 0.

Formulas to find Other Clearance

Other formulas in Elimination Rate Constant category

Go Elimination Half Life given Volume of Plasma Cleared

t b/2 = \frac{\ln (2) \cdot V d}{CL}

Go Elimination Half Life of Drug

t b/2 = \frac{\ln (2)}{k e}

Go Elimination Rate Constant given Area under Curve

k e = \frac{D}{AUC \cdot V d}

Go Elimination Rate Constant given Volume of Plasma Cleared

k e = \frac{CL}{V d}

How to Evaluate Total Clearance of Body?

Total Clearance of Body evaluator uses Total Clearance = Hepatic Clearance+Renal Clearance for Total+Pulmonary Clearance+Other Clearance to evaluate the Total Clearance, The Total Clearance of Body formula is defined as is the total clearance of a drug from the body. It is a measure of how quickly the drug is eliminated from the body. Total Clearance is denoted by CL_total symbol.

How to evaluate Total Clearance of Body using this online evaluator? To use this online evaluator for Total Clearance of Body, enter Hepatic Clearance (CL_hepatic), Renal Clearance for Total (CL_renal), Pulmonary Clearance (CL_pulmonary) & Other Clearance (CL_other) and hit the calculate button.

FAQs on Total Clearance of Body

What is the formula to find Total Clearance of Body?

The formula of Total Clearance of Body is expressed as Total Clearance = Hepatic Clearance+Renal Clearance for Total+Pulmonary Clearance+Other Clearance. Here is an example- 1.9E+7 = 4.16666666666667E-07+5.55555555555556E-07+4.16666666666667E-07+5.55555555555556E-08.

How to calculate Total Clearance of Body?

With Hepatic Clearance (CL_hepatic), Renal Clearance for Total (CL_renal), Pulmonary Clearance (CL_pulmonary) & Other Clearance (CL_other) we can find Total Clearance of Body using the formula - Total Clearance = Hepatic Clearance+Renal Clearance for Total+Pulmonary Clearance+Other Clearance.

Can the Total Clearance of Body be negative?

No, the Total Clearance of Body, measured in Volumetric Flow Rate cannot be negative.

Which unit is used to measure Total Clearance of Body?

Total Clearance of Body is usually measured using the Liter per hour[L/h] for Volumetric Flow Rate. Cubic Meter per Second[L/h], Cubic Meter per Day[L/h], Cubic Meter per Hour[L/h] are the few other units in which Total Clearance of Body can be measured.

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Total Clearance of Body Formula

Total Clearance of Body Example

Total Clearance of Body Solution

Total Clearance of Body Formula Elements

Other formulas in Elimination Rate Constant category

How to Evaluate Total Clearance of Body?

FAQs on Total Clearance of Body

Variable Name