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Therapeutic Index Formula

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The Therapeutic Index measure that reflects the safety of a drug by comparing its therapeutic dose (effective dose) to its toxic dose. Check FAQs
TI=LD50ED50
TI - Therapeutic Index?LD50 - Median Lethal Dose?ED50 - Median Effective Dose?

Therapeutic Index Example

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With units
Only example

Here is how the Therapeutic Index equation looks like with Values.

Here is how the Therapeutic Index equation looks like with Units.

Here is how the Therapeutic Index equation looks like.

7.5Edit=150Edit20Edit
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HomeIcon Home » Category Chemistry » Category Pharmacokinetics » Category Drug Content » fx Therapeutic Index

Therapeutic Index Solution

Follow our step by step solution on how to calculate Therapeutic Index?

FIRST Step Consider the formula
TI=LD50ED50
Next Step Substitute values of Variables
∴ TI=150mg20mg
Next Step Convert Units
∴ TI=0.0001kg2E-5kg
Next Step Prepare to Evaluate
∴ TI=0.00012E-5
LAST Step Evaluate
∴TI=7.5

Therapeutic Index Formula Elements

Variables
Therapeutic Index
The Therapeutic Index measure that reflects the safety of a drug by comparing its therapeutic dose (effective dose) to its toxic dose.
Symbol: TI
Measurement: NAUnit: Unitless
Note: Value should be greater than 0.
Formulas to find Therapeutic IndexOpen Variable
Median Lethal Dose
The Median Lethal Dose which represents the dose at which 50% of the population exhibits toxic effects or dies.
Symbol: LD50
Measurement: WeightUnit: mg
Note: Value should be greater than 0.
Formulas to find Median Lethal DoseOpen Variable
Median Effective Dose
The Median Effective Dose represents the dose at which 50% of the population exhibits the desired therapeutic effect.
Symbol: ED50
Measurement: WeightUnit: mg
Note: Value should be greater than 0.
Formulas to find Median Effective DoseOpen Variable

Other formulas in Drug Content category

​Go Apparent Volume of Drug Distribution
Vd=DCss
​Go Absorption Half-Life of Drug
ta/2=ln(2)ka
​Go Drug Rate Entering Body
ka=ln(2)ta/2
​Go Rate of Infusion of Drug
kin=CL⋅Css

How to Evaluate Therapeutic Index?

Therapeutic Index evaluator uses Therapeutic Index = Median Lethal Dose/Median Effective Dose to evaluate the Therapeutic Index, Therapeutic Index is defined as the ratio of the dose that produces toxicity to the dose that produces a clinically desired or effective response. Therapeutic Index is denoted by TI symbol.

How to evaluate Therapeutic Index using this online evaluator? To use this online evaluator for Therapeutic Index, enter Median Lethal Dose (LD50) & Median Effective Dose (ED50) and hit the calculate button.

FAQs on Therapeutic Index

What is the formula to find Therapeutic Index?
The formula of Therapeutic Index is expressed as Therapeutic Index = Median Lethal Dose/Median Effective Dose. Here is an example- 7.5 = 0.00015/2E-05.
How to calculate Therapeutic Index?
With Median Lethal Dose (LD50) & Median Effective Dose (ED50) we can find Therapeutic Index using the formula - Therapeutic Index = Median Lethal Dose/Median Effective Dose.
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