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Target Plasma Concentration given Maintenance Dose Formula

GoTarget Plasma Concentration given Revised Dose Formula

GoTarget Plasma Concentration given Loading Dose Formula

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The Target Plasma Concentration is refer to the desired or optimal concentration of a drug in the bloodstream at a specific time after the administration. Check FAQs

C p = (MD \cdot \frac{F%}{CL drug})

C_p - Target Plasma Concentration?MD - Maintenance Dose?F% - Bioavailability Of drug dose?CL_drug - Drug Clearance?

Target Plasma Concentration given Maintenance Dose Example

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With units

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Here is how the Target Plasma Concentration given Maintenance Dose equation looks like with Values.

Here is how the Target Plasma Concentration given Maintenance Dose equation looks like with Units.

Here is how the Target Plasma Concentration given Maintenance Dose equation looks like.

8.7E-6 = (70 \cdot \frac{0.9}{2})

8.7E-6mg/L = (70mg/h \cdot \frac{0.9}{2m³/s})

8.7E-6 = (70 \cdot \frac{0.9}{2})

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Target Plasma Concentration given Maintenance Dose Solution

Follow our step by step solution on how to calculate Target Plasma Concentration given Maintenance Dose?

FIRST Step Consider the formula

C p = (MD \cdot \frac{F%}{CL drug})

Next Step Substitute values of Variables

∴

C p = (70mg/h \cdot \frac{0.9}{2m³/s})

Next Step Convert Units

∴

C p = (1.9E-8kg/s \cdot \frac{0.9}{2m³/s})

Next Step Prepare to Evaluate

∴

C p = (1.9E-8 \cdot \frac{0.9}{2})

Next Step Evaluate

∴

C p = 8.74999999999998E-09kg/m³

Next Step Convert to Output's Unit

∴

C p = 8.74999999999998E-06mg/L

LAST Step Rounding Answer

∴

C p = 8.7E-6mg/L

Target Plasma Concentration given Maintenance Dose Formula Elements

Variables

Target Plasma Concentration

The Target Plasma Concentration is refer to the desired or optimal concentration of a drug in the bloodstream at a specific time after the administration.

Symbol: C_p

Measurement: Mass ConcentrationUnit: mg/L

Note: Value should be greater than 0.

Formulas to find Target Plasma Concentration

Maintenance Dose

The Maintenance Dose is the dose of a drug that is administered on a regular basis to maintained a desired plasma concentration.

Symbol: MD

Measurement: Mass Flow RateUnit: mg/h

Note: Value should be greater than 0.

Formulas to find Maintenance Dose

Bioavailability Of drug dose

The Bioavailability Of drug dose is describe the fraction or percentage of administration drug that reaches the systemic circulation in an unchanged and active form.

Symbol: F%

Measurement: NAUnit: Unitless

Note: Value can be positive or negative.

Formulas to find Bioavailability Of drug dose

Drug Clearance

Drug Clearance is the rate at which a drug or its metabolites are removed from the body and systemic circulation.

Symbol: CL_drug

Measurement: Volumetric Flow RateUnit: m³/s

Note: Value can be positive or negative.

Formulas to find Drug Clearance

Other Formulas to find Target Plasma Concentration

Go Target Plasma Concentration given Revised Dose

C p = \frac{RD \cdot M cpss}{PDR}

Go Target Plasma Concentration given Loading Dose

C p = \frac{LD \cdot F%}{V d}

Other formulas in Dose category

Go Amount of drug administered given apparent volume

D = V dis \cdot C ss

Go Amount of drug in given volume of plasma

C ss = \frac{D}{V dis}

Go Amount of drug administered given area under curve

D = CL \cdot AUC

Go Dose given volume of distribution and area under curve

D = V dis \cdot k e \cdot AUC

How to Evaluate Target Plasma Concentration given Maintenance Dose?

Target Plasma Concentration given Maintenance Dose evaluator uses Target Plasma Concentration = (Maintenance Dose*Bioavailability Of drug dose/Drug Clearance) to evaluate the Target Plasma Concentration, The Target Plasma Concentration given Maintenance Dose formula is defined as the ratio of the product of the maintenance dose and bioavailaility of drug to the clearance of drug. Target Plasma Concentration is denoted by C_p symbol.

How to evaluate Target Plasma Concentration given Maintenance Dose using this online evaluator? To use this online evaluator for Target Plasma Concentration given Maintenance Dose, enter Maintenance Dose (MD), Bioavailability Of drug dose (F%) & Drug Clearance (CL_drug) and hit the calculate button.

FAQs on Target Plasma Concentration given Maintenance Dose

What is the formula to find Target Plasma Concentration given Maintenance Dose?

The formula of Target Plasma Concentration given Maintenance Dose is expressed as Target Plasma Concentration = (Maintenance Dose*Bioavailability Of drug dose/Drug Clearance). Here is an example- 0.00875 = (1.94444444444444E-08*0.9/2).

How to calculate Target Plasma Concentration given Maintenance Dose?

With Maintenance Dose (MD), Bioavailability Of drug dose (F%) & Drug Clearance (CL_drug) we can find Target Plasma Concentration given Maintenance Dose using the formula - Target Plasma Concentration = (Maintenance Dose*Bioavailability Of drug dose/Drug Clearance).

What are the other ways to Calculate Target Plasma Concentration?

Here are the different ways to Calculate Target Plasma Concentration-

Target Plasma Concentration=(Revised Dose*Measured Steady State Concentration Plasma)/Previous Rate of Dose
Target Plasma Concentration=(Loading Dose*Bioavailability Of drug dose)/Volume Of Distribution dose

Can the Target Plasma Concentration given Maintenance Dose be negative?

No, the Target Plasma Concentration given Maintenance Dose, measured in Mass Concentration cannot be negative.

Which unit is used to measure Target Plasma Concentration given Maintenance Dose?

Target Plasma Concentration given Maintenance Dose is usually measured using the Milligram per Liter[mg/L] for Mass Concentration. Kilogram per Cubic Meter[mg/L], Kilogram per Liter[mg/L], Gram per Liter[mg/L] are the few other units in which Target Plasma Concentration given Maintenance Dose can be measured.

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