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Renal Clearance of Drug Formula

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Renal Clearance is a measure of kidney transport in units of volume of plasma per unit time. Check FAQs

CL r = \frac{A u}{AUC}

CL_r - Renal Clearance?A_u - Drug Amount Excreted Unchanged in Urine?AUC - Area Under Curve?

Renal Clearance of Drug Example

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Here is how the Renal Clearance of Drug equation looks like with Values.

Here is how the Renal Clearance of Drug equation looks like with Units.

Here is how the Renal Clearance of Drug equation looks like.

0.3727 = \frac{8.2}{1.32}

0.3727mL/min = \frac{8.2μg/L}{1.32mol*s/L}

0.3727 = \frac{8.2}{1.32}

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Renal Clearance of Drug Solution

Follow our step by step solution on how to calculate Renal Clearance of Drug?

FIRST Step Consider the formula

CL r = \frac{A u}{AUC}

Next Step Substitute values of Variables

∴

CL r = \frac{8.2μg/L}{1.32mol*s/L}

Next Step Convert Units

∴

CL r = \frac{8.2E-6kg/m³}{1320mol*s/m³}

Next Step Prepare to Evaluate

∴

CL r = \frac{8.2E-6}{1320}

Next Step Evaluate

∴

CL r = 6.21212121212121E-09m³/s

Next Step Convert to Output's Unit

∴

CL r = 0.372727272727273mL/min

LAST Step Rounding Answer

∴

CL r = 0.3727mL/min

Renal Clearance of Drug Formula Elements

Variables

Renal Clearance

Renal Clearance is a measure of kidney transport in units of volume of plasma per unit time.

Symbol: CL_r

Measurement: Volumetric Flow RateUnit: mL/min

Note: Value should be greater than 0.

Formulas to find Renal Clearance

Drug Amount Excreted Unchanged in Urine

Drug Amount Excreted Unchanged in Urine is the concentration of drug excreted through urine.

Symbol: A_u

Measurement: DensityUnit: μg/L

Note: Value should be greater than 0.

Formulas to find Drug Amount Excreted Unchanged in Urine

Area Under Curve

Area under Curve (AUC) is the definite integral of a curve that describes the variation of a drug concentration in blood plasma as a function of time.

Symbol: AUC

Measurement: Concentration Time CoefficientUnit: mol*s/L

Note: Value can be positive or negative.

Formulas to find Area Under Curve

How to Evaluate Renal Clearance of Drug?

Renal Clearance of Drug evaluator uses Renal Clearance = Drug Amount Excreted Unchanged in Urine/Area Under Curve to evaluate the Renal Clearance, The Renal Clearance of Drug formula is defined as a measure of kidney transport in units of volume of plasma per unit time. The volume of plasma measured is that volume for which a given substance (e.g., urea or drugs) is completely removed per minute. Renal Clearance is denoted by CL_r symbol.

How to evaluate Renal Clearance of Drug using this online evaluator? To use this online evaluator for Renal Clearance of Drug, enter Drug Amount Excreted Unchanged in Urine (A_u) & Area Under Curve (AUC) and hit the calculate button.

FAQs on Renal Clearance of Drug

What is the formula to find Renal Clearance of Drug?

The formula of Renal Clearance of Drug is expressed as Renal Clearance = Drug Amount Excreted Unchanged in Urine/Area Under Curve. Here is an example- 2.2E+7 = 8.2E-06/1320.

How to calculate Renal Clearance of Drug?

With Drug Amount Excreted Unchanged in Urine (A_u) & Area Under Curve (AUC) we can find Renal Clearance of Drug using the formula - Renal Clearance = Drug Amount Excreted Unchanged in Urine/Area Under Curve.

Can the Renal Clearance of Drug be negative?

No, the Renal Clearance of Drug, measured in Volumetric Flow Rate cannot be negative.

Which unit is used to measure Renal Clearance of Drug?

Renal Clearance of Drug is usually measured using the Milliliter per Minute[mL/min] for Volumetric Flow Rate. Cubic Meter per Second[mL/min], Cubic Meter per Day[mL/min], Cubic Meter per Hour[mL/min] are the few other units in which Renal Clearance of Drug can be measured.

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