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Maintenance Dose Formula

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The Maintenance Dose is the dose of a drug that is administered on a regular basis to maintained a desired plasma concentration. Check FAQs

MD = CL drug \cdot \frac{C p}{F%}

MD - Maintenance Dose?CL_drug - Drug Clearance?C_p - Target Plasma Concentration?F% - Bioavailability Of drug dose?

Maintenance Dose Example

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With units

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Here is how the Maintenance Dose equation looks like with Values.

Here is how the Maintenance Dose equation looks like with Units.

Here is how the Maintenance Dose equation looks like.

2.4E+8 = 2 \cdot \frac{30}{0.9}

2.4E+8mg/h = 2m³/s \cdot \frac{30mg/L}{0.9}

2.4E+8 = 2 \cdot \frac{30}{0.9}

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Maintenance Dose Solution

Follow our step by step solution on how to calculate Maintenance Dose?

FIRST Step Consider the formula

MD = CL drug \cdot \frac{C p}{F%}

Next Step Substitute values of Variables

∴

MD = 2m³/s \cdot \frac{30mg/L}{0.9}

Next Step Convert Units

∴

MD = 2m³/s \cdot \frac{0.03kg/m³}{0.9}

Next Step Prepare to Evaluate

∴

MD = 2 \cdot \frac{0.03}{0.9}

Next Step Evaluate

∴

MD = 0.0666666666666667kg/s

Next Step Convert to Output's Unit

∴

MD = 240000000mg/h

LAST Step Rounding Answer

∴

MD = 2.4E+8mg/h

Maintenance Dose Formula Elements

Variables

Maintenance Dose

The Maintenance Dose is the dose of a drug that is administered on a regular basis to maintained a desired plasma concentration.

Symbol: MD

Measurement: Mass Flow RateUnit: mg/h

Note: Value should be greater than 0.

Formulas to find Maintenance Dose

Drug Clearance

Drug Clearance is the rate at which a drug or its metabolites are removed from the body and systemic circulation.

Symbol: CL_drug

Measurement: Volumetric Flow RateUnit: m³/s

Note: Value can be positive or negative.

Formulas to find Drug Clearance

Target Plasma Concentration

The Target Plasma Concentration is refer to the desired or optimal concentration of a drug in the bloodstream at a specific time after the administration.

Symbol: C_p

Measurement: Mass ConcentrationUnit: mg/L

Note: Value should be greater than 0.

Formulas to find Target Plasma Concentration

Bioavailability Of drug dose

The Bioavailability Of drug dose is describe the fraction or percentage of administration drug that reaches the systemic circulation in an unchanged and active form.

Symbol: F%

Measurement: NAUnit: Unitless

Note: Value can be positive or negative.

Formulas to find Bioavailability Of drug dose

Other formulas in Dose category

Go Amount of drug administered given apparent volume

D = V dis \cdot C ss

Go Amount of drug in given volume of plasma

C ss = \frac{D}{V dis}

Go Amount of drug administered given area under curve

D = CL \cdot AUC

Go Dose given volume of distribution and area under curve

D = V dis \cdot k e \cdot AUC

How to Evaluate Maintenance Dose?

Maintenance Dose evaluator uses Maintenance Dose = Drug Clearance*Target Plasma Concentration/Bioavailability Of drug dose to evaluate the Maintenance Dose, The Maintenance Dose formula is defined as the dose of a drug that is administered on a regular basis to maintain a desired plasma concentration. Maintenance Dose is denoted by MD symbol.

How to evaluate Maintenance Dose using this online evaluator? To use this online evaluator for Maintenance Dose, enter Drug Clearance (CL_drug), Target Plasma Concentration (C_p) & Bioavailability Of drug dose (F%) and hit the calculate button.

FAQs on Maintenance Dose

What is the formula to find Maintenance Dose?

The formula of Maintenance Dose is expressed as Maintenance Dose = Drug Clearance*Target Plasma Concentration/Bioavailability Of drug dose. Here is an example- 8.6E+17 = 2*0.03/0.9.

How to calculate Maintenance Dose?

With Drug Clearance (CL_drug), Target Plasma Concentration (C_p) & Bioavailability Of drug dose (F%) we can find Maintenance Dose using the formula - Maintenance Dose = Drug Clearance*Target Plasma Concentration/Bioavailability Of drug dose.

Can the Maintenance Dose be negative?

No, the Maintenance Dose, measured in Mass Flow Rate cannot be negative.

Which unit is used to measure Maintenance Dose?

Maintenance Dose is usually measured using the Milligram per Hour[mg/h] for Mass Flow Rate. Kilogram per Second[mg/h], Gram per Second[mg/h], Gram per Hour[mg/h] are the few other units in which Maintenance Dose can be measured.

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