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Elimination Half Life given Volume of Plasma Cleared Formula

GoElimination Half Life of Drug Formula

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Elimination Half Life is the time required for the concentration of the drug to reach half of its original value. Check FAQs

t b/2 = \frac{\ln (2) \cdot V d}{CL}

t_b/2 - Elimination Half Life?V_d - Volume of Distribution?CL - Volume of Plasma Cleared?

Elimination Half Life given Volume of Plasma Cleared Example

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Here is how the Elimination Half Life given Volume of Plasma Cleared equation looks like with Values.

Here is how the Elimination Half Life given Volume of Plasma Cleared equation looks like with Units.

Here is how the Elimination Half Life given Volume of Plasma Cleared equation looks like.

12.9965 = \frac{\ln (2) \cdot 9}{0.48}

12.9965s = \frac{\ln (2) \cdot 9L}{0.48L/s}

12.9965 = \frac{\ln (2) \cdot 9}{0.48}

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Elimination Rate Constant » fx Elimination Half Life given Volume of Plasma Cleared

Elimination Half Life given Volume of Plasma Cleared Solution

Follow our step by step solution on how to calculate Elimination Half Life given Volume of Plasma Cleared?

FIRST Step Consider the formula

t b/2 = \frac{\ln (2) \cdot V d}{CL}

Next Step Substitute values of Variables

∴

t b/2 = \frac{\ln (2) \cdot 9L}{0.48L/s}

Next Step Convert Units

∴

t b/2 = \frac{\ln (2) \cdot 0.009m³}{0.0005m³/s}

Next Step Prepare to Evaluate

∴

t b/2 = \frac{\ln (2) \cdot 0.009}{0.0005}

Next Step Evaluate

∴

t b/2 = 12.996509635499s

LAST Step Rounding Answer

∴

t b/2 = 12.9965s

Elimination Half Life given Volume of Plasma Cleared Formula Elements

Variables

Functions

Elimination Half Life

Elimination Half Life is the time required for the concentration of the drug to reach half of its original value.

Symbol: t_b/2

Measurement: TimeUnit: s

Note: Value should be greater than 0.

Formulas to find Elimination Half Life

Volume of Distribution

The Volume of Distribution is the parameter relating drug concentration in plasma to drug amount in the body.

Symbol: V_d

Measurement: VolumeUnit: L

Note: Value can be positive or negative.

Formulas to find Volume of Distribution

Volume of Plasma Cleared

The Volume of Plasma Cleared is defined as the amount of plasma cleared of the drug per unit of time.

Symbol: CL

Measurement: Volumetric Flow RateUnit: L/s

Note: Value can be positive or negative.

Formulas to find Volume of Plasma Cleared

The natural logarithm, also known as the logarithm to the base e, is the inverse function of the natural exponential function.

Syntax: ln(Number)

Other Formulas to find Elimination Half Life

Go Elimination Half Life of Drug

t b/2 = \frac{\ln (2)}{k e}

Other formulas in Elimination Rate Constant category

Go Elimination Rate Constant given Area under Curve

k e = \frac{D}{AUC \cdot V d}

Go Elimination Rate Constant given Volume of Plasma Cleared

k e = \frac{CL}{V d}

Go Elimination Rate Constant of Drug

k e = \frac{\ln (2)}{t b/2}

Go Total Clearance of Body

CL total = CL hepatic + CL renal + CL pulmonary + CL other

How to Evaluate Elimination Half Life given Volume of Plasma Cleared?

Elimination Half Life given Volume of Plasma Cleared evaluator uses Elimination Half Life = (ln(2)*Volume of Distribution)/Volume of Plasma Cleared to evaluate the Elimination Half Life, The Elimination half life given volume of plasma cleared formula is defined as the direct relation with the apparent volume in which a drug is distributed and an inverse relationship with the volume of plasma cleared of the drug per unit time. Elimination Half Life is denoted by t_b/2 symbol.

How to evaluate Elimination Half Life given Volume of Plasma Cleared using this online evaluator? To use this online evaluator for Elimination Half Life given Volume of Plasma Cleared, enter Volume of Distribution (V_d) & Volume of Plasma Cleared (CL) and hit the calculate button.

FAQs on Elimination Half Life given Volume of Plasma Cleared

What is the formula to find Elimination Half Life given Volume of Plasma Cleared?

The formula of Elimination Half Life given Volume of Plasma Cleared is expressed as Elimination Half Life = (ln(2)*Volume of Distribution)/Volume of Plasma Cleared. Here is an example- 12.99651 = (ln(2)*0.009)/0.00048.

How to calculate Elimination Half Life given Volume of Plasma Cleared?

With Volume of Distribution (V_d) & Volume of Plasma Cleared (CL) we can find Elimination Half Life given Volume of Plasma Cleared using the formula - Elimination Half Life = (ln(2)*Volume of Distribution)/Volume of Plasma Cleared. This formula also uses Natural Logarithm (ln) function(s).

What are the other ways to Calculate Elimination Half Life?

Here are the different ways to Calculate Elimination Half Life-

Elimination Half Life=ln(2)/Elimination Rate Constant

Can the Elimination Half Life given Volume of Plasma Cleared be negative?

No, the Elimination Half Life given Volume of Plasma Cleared, measured in Time cannot be negative.

Which unit is used to measure Elimination Half Life given Volume of Plasma Cleared?

Elimination Half Life given Volume of Plasma Cleared is usually measured using the Second[s] for Time. Millisecond[s], Microsecond[s], Nanosecond[s] are the few other units in which Elimination Half Life given Volume of Plasma Cleared can be measured.

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