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Dissociation Constant in presence of Noncompetitive Inhibitor Formula

GoDissociation Constant given Apparent Initial Enzyme Concentration Formula

GoDissociation Constant given Enzyme Substrate Complex Concentration Formula

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The Enzyme Inhibitor Dissociation Constant is measured by the method in which the inhibitor is titrated into a solution of enzyme and the heat released or absorbed is measured. Check FAQs

K i = (\frac{I}{(\frac{V max}{Vmax app}) - 1})

K_i - Enzyme Inhibitor Dissociation Constant?I - Inhibitor Concentration?V_max - Maximum Rate?Vmax^app - Apparent Maximum Rate?

Dissociation Constant in presence of Noncompetitive Inhibitor Example

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Here is how the Dissociation Constant in presence of Noncompetitive Inhibitor equation looks like with Values.

Here is how the Dissociation Constant in presence of Noncompetitive Inhibitor equation looks like with Units.

Here is how the Dissociation Constant in presence of Noncompetitive Inhibitor equation looks like.

9.9474 = (\frac{9}{(\frac{40}{21}) - 1})

9.9474mol/L = (\frac{9mol/L}{(\frac{40mol/L*s}{21mol/L*s}) - 1})

9.9474 = (\frac{9}{(\frac{40}{21}) - 1})

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Enzyme Kinetics » fx Dissociation Constant in presence of Noncompetitive Inhibitor

Dissociation Constant in presence of Noncompetitive Inhibitor Solution

Follow our step by step solution on how to calculate Dissociation Constant in presence of Noncompetitive Inhibitor?

FIRST Step Consider the formula

K i = (\frac{I}{(\frac{V max}{Vmax app}) - 1})

Next Step Substitute values of Variables

∴

K i = (\frac{9mol/L}{(\frac{40mol/L*s}{21mol/L*s}) - 1})

Next Step Convert Units

∴

K i = (\frac{9000mol/m³}{(\frac{40000mol/m³*s}{21000mol/m³*s}) - 1})

Next Step Prepare to Evaluate

∴

K i = (\frac{9000}{(\frac{40000}{21000}) - 1})

Next Step Evaluate

∴

K i = 9947.36842105263mol/m³

Next Step Convert to Output's Unit

∴

K i = 9.94736842105263mol/L

LAST Step Rounding Answer

∴

K i = 9.9474mol/L

Dissociation Constant in presence of Noncompetitive Inhibitor Formula Elements

Variables

Enzyme Inhibitor Dissociation Constant

The Enzyme Inhibitor Dissociation Constant is measured by the method in which the inhibitor is titrated into a solution of enzyme and the heat released or absorbed is measured.

Symbol: K_i

Measurement: Molar ConcentrationUnit: mol/L

Note: Value can be positive or negative.

Formulas to find Enzyme Inhibitor Dissociation Constant

Inhibitor Concentration

The Inhibitor concentration is defined as the number of moles of inhibitor present per liter of solution of the system.

Symbol: I

Measurement: Molar ConcentrationUnit: mol/L

Note: Value can be positive or negative.

Formulas to find Inhibitor Concentration

Maximum Rate

The Maximum Rate is defined as the maximum speed achieved by the system at saturated substrate concentration.

Symbol: V_max

Measurement: Reaction RateUnit: mol/L*s

Note: Value can be positive or negative.

Formulas to find Maximum Rate

Apparent Maximum Rate

Apparent Maximum Rate is defined as the maximum speed achieved by the system at saturated substrate concentration in presence of non-competitive inhibitor.

Symbol: Vmax^app

Measurement: Reaction RateUnit: mol/L*s

Note: Value can be positive or negative.

Formulas to find Apparent Maximum Rate

Other Formulas to find Enzyme Inhibitor Dissociation Constant

Go Dissociation Constant given Apparent Initial Enzyme Concentration

K i = (\frac{I}{(\frac{[E 0]}{E0 app}) - 1})

Go Dissociation Constant given Enzyme Substrate Complex Concentration

K i = \frac{I}{(\frac{(\frac{[E 0] \cdot S}{ES}) - S}{K M}) - 1}

Other formulas in Noncompetitive Inhibitor category

Go Apparent Initial Enzyme Concentration in Presence of Noncompetitive Inhibitor

E0 app = (\frac{[E 0]}{1 + (\frac{I}{K i})})

Go Apparent Maximum Rate in presence of Noncompetitive Inhibitor

Vmax app = (\frac{V max}{1 + (\frac{I}{K i})})

Go Apparent Michaelis Menten constant given Inhibitor's Dissociation Constant

Km app = K M \cdot (1 + (\frac{I}{K i}))

Go Maximum Rate in presence of Noncompetitive Inhibitor

V max = (Vmax app \cdot (1 + (\frac{I}{K i})))

How to Evaluate Dissociation Constant in presence of Noncompetitive Inhibitor?

Dissociation Constant in presence of Noncompetitive Inhibitor evaluator uses Enzyme Inhibitor Dissociation Constant = (Inhibitor Concentration/((Maximum Rate/Apparent Maximum Rate)-1)) to evaluate the Enzyme Inhibitor Dissociation Constant, The Dissociation constant in presence of noncompetitive inhibitor formula is defined as a relation with the apparent maximum rate of the system, inhibitor concentration, and maximum rate of the system. Enzyme Inhibitor Dissociation Constant is denoted by K_i symbol.

How to evaluate Dissociation Constant in presence of Noncompetitive Inhibitor using this online evaluator? To use this online evaluator for Dissociation Constant in presence of Noncompetitive Inhibitor, enter Inhibitor Concentration (I), Maximum Rate (V_max) & Apparent Maximum Rate (Vmax^app) and hit the calculate button.

FAQs on Dissociation Constant in presence of Noncompetitive Inhibitor

What is the formula to find Dissociation Constant in presence of Noncompetitive Inhibitor?

The formula of Dissociation Constant in presence of Noncompetitive Inhibitor is expressed as Enzyme Inhibitor Dissociation Constant = (Inhibitor Concentration/((Maximum Rate/Apparent Maximum Rate)-1)). Here is an example- 0.009947 = (9000/((40000/21000)-1)).

How to calculate Dissociation Constant in presence of Noncompetitive Inhibitor?

With Inhibitor Concentration (I), Maximum Rate (V_max) & Apparent Maximum Rate (Vmax^app) we can find Dissociation Constant in presence of Noncompetitive Inhibitor using the formula - Enzyme Inhibitor Dissociation Constant = (Inhibitor Concentration/((Maximum Rate/Apparent Maximum Rate)-1)).

What are the other ways to Calculate Enzyme Inhibitor Dissociation Constant?

Here are the different ways to Calculate Enzyme Inhibitor Dissociation Constant-

Enzyme Inhibitor Dissociation Constant=(Inhibitor Concentration/((Initial Enzyme Concentration/Apparent Initial Enzyme Concentration)-1))
Enzyme Inhibitor Dissociation Constant=Inhibitor Concentration/(((((Initial Enzyme Concentration*Substrate Concentration)/Enzyme Substrate Complex Concentration)-Substrate Concentration)/Michaelis Constant)-1)

Can the Dissociation Constant in presence of Noncompetitive Inhibitor be negative?

Yes, the Dissociation Constant in presence of Noncompetitive Inhibitor, measured in Molar Concentration can be negative.

Which unit is used to measure Dissociation Constant in presence of Noncompetitive Inhibitor?

Dissociation Constant in presence of Noncompetitive Inhibitor is usually measured using the Mole per Liter[mol/L] for Molar Concentration. Mole per Cubic Meter[mol/L], Mole per Cubic Millimeter[mol/L], Kilomole per Cubic Meter[mol/L] are the few other units in which Dissociation Constant in presence of Noncompetitive Inhibitor can be measured.

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Dissociation Constant in presence of Noncompetitive Inhibitor Formula

​GoDissociation Constant given Apparent Initial Enzyme Concentration Formula

​GoDissociation Constant given Enzyme Substrate Complex Concentration Formula

Dissociation Constant in presence of Noncompetitive Inhibitor Example

Dissociation Constant in presence of Noncompetitive Inhibitor Solution

Dissociation Constant in presence of Noncompetitive Inhibitor Formula Elements

Other Formulas to find Enzyme Inhibitor Dissociation Constant

Other formulas in Noncompetitive Inhibitor category

How to Evaluate Dissociation Constant in presence of Noncompetitive Inhibitor?

FAQs on Dissociation Constant in presence of Noncompetitive Inhibitor

Variable Name

GoDissociation Constant given Apparent Initial Enzyme Concentration Formula

GoDissociation Constant given Enzyme Substrate Complex Concentration Formula