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Clearance of Drug given Maintenance Dose Formula

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Drug Clearance is the rate at which a drug or its metabolites are removed from the body and systemic circulation. Check FAQs

CL drug = \frac{MD \cdot f}{C p}

CL_drug - Drug Clearance?MD - Maintenance Dose?f - Bioavailability of Drug?C_p - Target Plasma Concentration?

Clearance of Drug given Maintenance Dose Example

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Here is how the Clearance of Drug given Maintenance Dose equation looks like with Values.

Here is how the Clearance of Drug given Maintenance Dose equation looks like with Units.

Here is how the Clearance of Drug given Maintenance Dose equation looks like.

6.2E-6 = \frac{70 \cdot 9.5}{30}

6.2E-6m³/s = \frac{70mg/h \cdot 9.5}{30mg/L}

6.2E-6 = \frac{70 \cdot 9.5}{30}

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Clearance of Drug given Maintenance Dose Solution

Follow our step by step solution on how to calculate Clearance of Drug given Maintenance Dose?

FIRST Step Consider the formula

CL drug = \frac{MD \cdot f}{C p}

Next Step Substitute values of Variables

∴

CL drug = \frac{70mg/h \cdot 9.5}{30mg/L}

Next Step Convert Units

∴

CL drug = \frac{1.9E-8kg/s \cdot 9.5}{0.03kg/m³}

Next Step Prepare to Evaluate

∴

CL drug = \frac{1.9E-8 \cdot 9.5}{0.03}

Next Step Evaluate

∴

CL drug = 6.15740740740739E-06m³/s

LAST Step Rounding Answer

∴

CL drug = 6.2E-6m³/s

Clearance of Drug given Maintenance Dose Formula Elements

Variables

Drug Clearance

Drug Clearance is the rate at which a drug or its metabolites are removed from the body and systemic circulation.

Symbol: CL_drug

Measurement: Volumetric Flow RateUnit: m³/s

Note: Value can be positive or negative.

Formulas to find Drug Clearance

Maintenance Dose

The Maintenance Dose is the dose of a drug that is administered on a regular basis to maintained a desired plasma concentration.

Symbol: MD

Measurement: Mass Flow RateUnit: mg/h

Note: Value should be greater than 0.

Formulas to find Maintenance Dose

Bioavailability of Drug

The Bioavailability of Drug is defined as the systemically available fraction of a drug.

Symbol: f

Measurement: NAUnit: Unitless

Note: Value can be positive or negative.

Formulas to find Bioavailability of Drug

Target Plasma Concentration

The Target Plasma Concentration is refer to the desired or optimal concentration of a drug in the bloodstream at a specific time after the administration.

Symbol: C_p

Measurement: Mass ConcentrationUnit: mg/L

Note: Value should be greater than 0.

Formulas to find Target Plasma Concentration

Other formulas in Dose category

Go Amount of drug administered given apparent volume

D = V dis \cdot C ss

Go Amount of drug in given volume of plasma

C ss = \frac{D}{V dis}

Go Amount of drug administered given area under curve

D = CL \cdot AUC

Go Dose given volume of distribution and area under curve

D = V dis \cdot k e \cdot AUC

How to Evaluate Clearance of Drug given Maintenance Dose?

Clearance of Drug given Maintenance Dose evaluator uses Drug Clearance = (Maintenance Dose*Bioavailability of Drug)/Target Plasma Concentration to evaluate the Drug Clearance, The Clearance of Drug given Maintenance Dose formula is defined as ratio of the product of the maintenance dose and bioavailability of drug to the target plasma concentration. Drug Clearance is denoted by CL_drug symbol.

How to evaluate Clearance of Drug given Maintenance Dose using this online evaluator? To use this online evaluator for Clearance of Drug given Maintenance Dose, enter Maintenance Dose (MD), Bioavailability of Drug (f) & Target Plasma Concentration (C_p) and hit the calculate button.

FAQs on Clearance of Drug given Maintenance Dose

What is the formula to find Clearance of Drug given Maintenance Dose?

The formula of Clearance of Drug given Maintenance Dose is expressed as Drug Clearance = (Maintenance Dose*Bioavailability of Drug)/Target Plasma Concentration. Here is an example- 6.2E-6 = (1.94444444444444E-08*9.5)/0.03.

How to calculate Clearance of Drug given Maintenance Dose?

With Maintenance Dose (MD), Bioavailability of Drug (f) & Target Plasma Concentration (C_p) we can find Clearance of Drug given Maintenance Dose using the formula - Drug Clearance = (Maintenance Dose*Bioavailability of Drug)/Target Plasma Concentration.

Can the Clearance of Drug given Maintenance Dose be negative?

Yes, the Clearance of Drug given Maintenance Dose, measured in Volumetric Flow Rate can be negative.

Which unit is used to measure Clearance of Drug given Maintenance Dose?

Clearance of Drug given Maintenance Dose is usually measured using the Cubic Meter per Second[m³/s] for Volumetric Flow Rate. Cubic Meter per Day[m³/s], Cubic Meter per Hour[m³/s], Cubic Meter per Minute[m³/s] are the few other units in which Clearance of Drug given Maintenance Dose can be measured.

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